People with high blood pressure who take paracetamol on prescription could be increasing their risk of heart attacks and strokes, a study suggests.
Doctors should think about the risks and benefits to patients taking it over many months, the University of Edinburgh researchers say.
Taking the painkiller for headaches and fevers is safe, they stress.
Other experts say research in more people over a longer timeframe is needed to confirm the findings.
Paracetamol is widely used around the world as a short-term remedy for aches and pains but also prescribed to manage chronic pain, despite little evidence of its benefit for long-term use.
Half a million people - one out of every 10 - in Scotland were prescribed the painkiller in 2018.
If they also have high blood pressure, a condition that affects one in every three people in the UK, they may be more at risk, according to this trial.
It tracked 110 volunteers, two-thirds of whom were taking drugs for high blood pressure, or hypertension.
In a randomised trial, they were asked to take 1g of paracetamol four times a day for two weeks - a common dose for patients with chronic pain - and then dummy pills, or placebo, for another two weeks.
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